Table 1.
Pathogen interactions with Factor H family proteins.
| Pathogen | Factor H binding ligand(other name designations) | Binding domains of Factor H family proteins | References |
|---|---|---|---|
| Bacteria | |||
| Acinetobacter baumannii | AbOmpA | FH | (71) |
| Bacillus anthracis | BclA | FH | (72) |
| Bordetella parapertussis, pertussis | ? | 5–7 (FH, FHL-1); 19–20 (FH); FHR-1 | (73, 74) |
| Borrelia afzelii | CspA (BaCRASP-1) | 5–7 (FH, FHL-1) | (75–78) |
| CspZ (CRASP-2, BBH06) | 6–7 (FH, FHL-1) | (75, 77, 78) | |
| BaCRASP-3 | 6–7 (FHL-1) | (77) | |
| BaCRASP-4 | 19–20 (FH) | (77) | |
| BaCRASP-5 | 19–20 (FH) | (77) | |
| BAPKO_0422 | FH | (79) | |
| Borrelia burgdorferi | CspA (CRASP-1, BbCRASP-1, BBA68, FHBP) | 5–7 (FH, FHL-1); 19–20 (FH) | (75, 77, 80) |
| CspZ (CRASP-2, BbCRASP-2, BBH06) | 7 (FH, FHL-1) | (77, 81) | |
| ErpP (CRASP-3, BbCRASP-3, BBN38) | 19–20 (FH); FHR-1, -2, -5 | (77, 82, 83)# | |
| ErpC (CRASP-4, BbCRASP-4) | FH; FHR-1, -2 | (77, 83)# | |
| ErpA (CRASP-5, BbCRASP-5, ErpI, ErpN, BBP38, BBl39, OspE) | 19–20 (FH); FHR-1, -2, -5 | (74, 77, 83–85)# | |
| Borrelia hermsii | BhCRASP-1 (FhbA, FHBP19) | 16–20 (FH); FHL-1; FHR-1 | (86–88) |
| Borrelia mayonii | CspA | 5–7 (FH, FHL-1) | (89) |
| Borrelia miyamotoi | CbiA | 20 (FH) | (90) |
| Borrelia parkeri | BpcA | 19–20 (FH); FHR-1 | (91) |
| Borrelia recurrentis | HcpA | 19–20 (FH); FHR-1 | (92) |
| ? | FH | (93) | |
| Borrelia spielmanii | CspA (BsCRASP-1) | 5–7 (FH, FHL-1) | (94–96) |
| BsCRASP-2 | FH; FHL-1 | (94) | |
| BsCRASP-3 | 20 (FH); FHL-1; FHR-1 | (94, 96) | |
| Escherichia coli | Stx2 | 6–8 (FH, FHL-1); 18–20 (FH); 3–5 (FHR) | (97, 98) |
| OmpW | FH | (99) | |
| Francisella tularensis | ? | FH | (100) |
| Fusobacterium necrophorum | ? | 5–7 (FH, FHL-1); 19–20 (FH); FHR-1, -4 | (101) |
| Haemophilus influenzae type b and f | Protein H (PH) | 7 (FH, FHL-1); 18–20 (FH) | (102, 103) |
| Histophilus somni | ? | FH | (104) |
| Leptospira spp | LenA (LfhA, Lsa24) | 18–20 (FH, FHR-1) | (105) |
| Len B | FH | (106) | |
| LcpA | 20 (FH) | (107) | |
| LigA, LigB | 5–7 (FH, FHL-1); 18–20 (FH); FHR-1 | (108, 109) | |
| Lsa23 | FH | (110, 111) | |
| LIC11966/ErpY-like lipoprotein | FH | (112) | |
| EF-Tu | FH | (113) | |
| ? | FH | (114) | |
| Enolase | FH | (115) | |
| Moraxella catarrhalis | OlpA | FH | (116) |
| Mycoplasma hyopneumoniae | EF-Tu | FH | (66) |
| Neisseria cinerea | FHbp | FH | (117) |
| Neisseria gonorrhoeae | PorB.1A (PorB1a, Por1A) | 6 (FH, FHL-1); 18–20 (FH); FHR-1 | (118, 119) |
| PorB.1B (PorB1b, Por1B) | 18–20 (FH) | (118–120) | |
| NspA | 6–7 (FH, FHL-1) | (121) | |
| Neisseria meningitidis | FHbp | 6–7 (FH) | (122, 123) |
| NspA | 6–7 (FH, FHL-1) | (124) | |
| PorB2 | 6–7 (FH, FHL-1) | (125) | |
| PorB3 | 6–7 (FH) | (126) | |
| LOS sialylation | 18–20 (FH) | (127) | |
| Non‐typeable Haemophilus influenzae | OmpP5 (P5) | 6–7 (FH) | (128, 129) |
| Pasteurella pneumotropica | ? | FH | (130) |
| Pseudomonas aeruginosa | Lpd | 7 (FH, FHL-1); 18–20 (FH); 3–5 (FHR-1) | (131) |
| Tuf | 6–7 (FH, FHL-1); 19–20 (FH); 3–5 (FHR-1) | (74, 132) | |
| Rickettsia conorii | OmpB β-peptide | FH | (133) |
| Salmonella spp | Rck | 5–7, 19–20 (FH) | (134) |
| Staphylococcus aureus | SdrE | 20 (FH) | (135, 136) |
| Sbi | 19–20 (FH); FHR-1 | (137) | |
| Streptococcus agalactiae | β protein (Bac, β C) | 8–11, 12–14 (FH) | (138, 139) |
| Sht I and II | FH | (140, 141) | |
| Streptococcus pneumoniae | PspC (CbpA, SpA, Hic, C3-binding protein) | 6–10, 8–10, 9, 8–11, 19–20, 13–15 (FH) | (65, 139, 142–148) |
| Tuf | 6–7 (FH, FHL-1); 18–20 (FH); 3–5 (FHR-1) | (149) | |
| LytA | FH | (150) | |
| Streptococcus pyogenes | Fba | 7 (FH, FHL-1) | (151, 152) |
| M protein family | 7 (FH, FHL-1) | (153–155) | |
| Scl1 | 19–20 (FH); 3–5 (FHR-1) | (156, 157) | |
| Streptococcus suis | Fhb | FH | (158) |
| Enolase, EF-Tu, PK, GAPDH, FBA, FBPS, KAR, MRP1 | FH | (99) | |
| Treponema denticola | FhbB | 7 (FH) | (68, 70, 159) |
| Yersinia enterocolitica | YadA | FH | (160) |
| Ail | 6–7 (FH) | (160) | |
| Yersinia pseudotuberculosis | Ail | 5–7, 19–20 (FH) | (161) |
| Fungi | |||
| Aspergillus fumigatus | AfEno1 | 6–7 (FH, FHL-1); 19–20 (FH) | (162) |
| Aspf2 | 6–7 (FH, FHL-1); 19–20 (FH); 3–5 (FHR-1) | (163) | |
| Candida albicans | Pra1 | 5–7 (FH, FHL-1); 16–20 (FH) | (164) |
| Gpm1p (CRASP 1) | 6–7 (FH, FHL-1); 19–20 (FH) | (165) | |
| Gpd2 (Gapdh) | 7 (FH, FHL-1) | (166) | |
| Hgt1p | 6–7 (FH) | (167, 168) | |
| Protozoa | |||
| Trypanosoma brucei | FHR | 4–6 (FH) | (169) |
| Trypanosoma cruzi | ? | FH | (170) |
| Plasmodium falciparum | ? | 5 (FH, FHL-1); 20 (FH); FHR-1 | (171) |
| PfGAP50 | 5–7 (FH, FHL-1) | (172) | |
| Pf92 | 5–6 (FH, FHL-1) | (173) | |
| Helminths | |||
| Toxoplasma gondii | ? | FH | (174) |
| Onchocerca volvulus | ? | (8–20) FH | (175) |
| Echinococcus granulosus | ? | FH | (176) |
| Loa Loa | ? | FH | (177) |
| Viruses | |||
| West Nile virus | NS1 | FH | (178) |
| Human immunodeficiency virus-1 | gp41, gp120 | FH | (179–182) |
#Reviewed in.