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. 2021 Feb 25;12:620238. doi: 10.3389/fimmu.2021.620238

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Copyright © 2021 Dong, Xue, Fan, Zhang, Wang, Li and Da

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pin1 regulates NLRP3 inflammasome expression by promoting phosphorylation of p38 MAPK pathway. (A) Analysis of one published septic shock clinical data set (GSE26440), revealed that p38 MAPK expression is upregulated in septic shock. (B) Immunoblot analysis for activation of p38 MAPK, ERK, and JNK in cell lysates from WT and Pin1^-/- bone marrow-derived macrophages (BMDMs) and stimulated with LPS (500 ng/ml) for 0, 10, 20, and 30 min. (C) Immunoblot analysis for activation of p38 MAPK in RAW 264.7 cells transfected with control siRNA or siPin1 for 0, 10, 20, and 30 min. (D) Correlation analysis between Pin1 and p38 MAPK in GSE26440. (E) BMDMs were collected to perform co-immunoprecipitation with p-p38 MAPK or Pin1. (F) Dot blot analysis for detecting the interaction between Pin1 and p38 phosphopeptide (T180(P)). The numbers 1,2,3 represent three repetitions.

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