Figure 1.

Study flow diagram. In subproject 1, after recruitment and eligibility checks, 1,800 participants will be randomized into six monotherapy groups. Through an 8-week multidimensional evaluation, we will screen potential biomarkers and build a prediction model. Then, the verification part and add-on treatment will be carried out in subproject 2. Finally, we will conduct a randomized double-blind controlled trial to summarize a comprehensive intervention strategy for metabolic syndrome (MetS).