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. 2021 Feb 25;12:554621. doi: 10.3389/fpsyt.2021.554621

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Copyright © 2021 Yao, Zhang, Feng, Gao, Shen, Liu and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Database survey and protein–protein interaction network analysis on the 59 blood-secretory proteins. (A) Compared with plasma protein database. (B) Compared with ASD-related database (AutismKB). *The AutismKB database contains 1,379 genes, 5,420 copy number variants (CNVs)/structural variations (SVs), 11,669 single-nucleotide variations (SNVs)/insertions and deletions (InDels), and 172 linkage regions associated with ASD. (C) The blood-secretory proteins overlapped in plasma protein database and AutismKB database. (D) The protein–protein interaction network of these 59 blood-secretory proteins. The predicted blood-secretory proteins are shown as red nodes and autism pathology-related proteins are shown as blue nodes. (E) UniProt keywords were enriched by using String database. Gene with a node color of purplish red, whose Uniprot keyword is alternative splicing.