Table 1.
Six predicted blood-secretory proteins selected for validation in this study.
| No. | Gene | UniProt ID | Proteina | Functionb |
|---|---|---|---|---|
| 1 | RARS | P54136 | Arginine–tRNA ligase, cytoplasmic | Protein synthesis, inflammatory |
| 2 | ACTL6B | O94805 | Actin-like protein 6B | Transcriptional activation and chromatin remodeling |
| 3 | ARHGEF4 | Q9NR80 | Rho guanine nucleotide exchange factor 4 | High levels in the brain and is involved in cell migration and cell–cell adhesion |
| 4 | PRKAA1 | Q13131 | 5′-AMP-activated protein kinase catalytic subunit alpha-1 | Cellular energy metabolism, cell growth and proliferation, phosphorylation |
| 5 | SLC25A12 | O75746 | Calcium-binding mitochondrial carrier protein Aralar1 | Calcium ion binding, amino acid metabolism |
| 6 | LIMK1 | P53667 | LIM domain kinase 1 | Stimulates axonal outgrowth and may be involved in brain development |
a
Except RARS did not match the two databases (i.e., AutismKB and plasma protein database), all the other proteins were matched. However, RARS has important functions and may be implied in the pathogenesis of ASD.
b
Functional information obtained from UniProt database (https://www.uniprot.org/).