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. 2021 Feb 25;12:643472. doi: 10.3389/fmicb.2021.643472

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Copyright © 2021 Zhou, Bi, Ding and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Vitamin C biosynthesis pathway reconstructed in S. cerevisiae. The following enzymes are involved: HK, hexokinase; GPI, glucose-6-phosphate isomerase; MPI, mannose-6-phosphate isomerase; PMM, phosphomannomutase; GMP, GDP-mannose pyrophosphorylase; GME, GDP-mannose-3,5-epimerase; GGP, GDP-L-galactose phosphorylase; GPP, L-Galactose 1-phosphate phosphatase; ARA, D-Arabinose dehydrogenase; ALO, D-Arabinono-1,4-Lactone Oxidase; L-GalDH, L-galactose dehydrogenase; L-GLDH, L-galactono-1,4-lactone dehydrogenase. The introduced genes from Arabidopsis are marked in green.