Fig. 7.

The antinociceptive effects of subchronic curcumin in the formalin test. (A) The effect of subchronic curcumin administration on formalin-induced pain behavior was measured. Mice were treated with curcumin (30 mg/kg, i.p.) or vehicle for 6 days once daily and were challenged with curcumin (30 mg/kg, i.p.) on day 7 and tested in a formalin (2.5%) test. A vehicle control group, in which mice were exposed to 7 days of vehicle, was also included. (B) The antiedema effect of formalin injection of curcumin, measured by the difference in the ipsilateral paw diameter before and after formalin injection (ΔPD), was assessed 1 hour after formalin injection. Data are given as the mean ± S.E.M. of six animals for each group. *P < 0.05, significantly different from its vehicle group.