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. 2021 Feb 25;9:633704. doi: 10.3389/fcell.2021.633704

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Copyright © 2021 Munro, van Hout, Aitken-Buck, Sugunesegran, Bhagwat, Davis, Lamberts, Coffey, Soeller and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RyR2 super-cluster properties are unaltered in human AF. Demonstration of super-cluster analysis performed on rendered dSTORM images of RyR2 clusters in a non-AF patient RAA, including (A) original rendered image, (B) mask generated after application of threshold, and (C) detection of super-clusters, with examples shown in panels i–iii. (A–C) Scale bar = 1 μm; panels i–iii scale bar = 0.5 μm. Analysis reveals the mean (D) percentage of clusters within 150 nm of nearest neighbor, (E) number of clusters in a super-cluster, and (F) super-cluster nearest neighbor distance in the RAA of non-AF, paroxysmal AF, and persistent AF patients. Data displayed as mean ± SEM. All analyses performed with one-way ANOVA; non-AF n = 9, paroxysmal AF n = 8, persistent AF n = 7.