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. 2021 Feb 25;9:636498. doi: 10.3389/fcell.2021.636498

FIGURE 1.

FIGURE 1

Withaferin A increases the grip strength and myofiber size of female NSG mice. Quantification of mean (A) forelimb and (B) total limb grip strength normalized to body weight in tumor-free and tumor-bearing vehicle-treated, WFA 2 mg/kg, and WFA 4 mg/kg groups at week four post-xenografting of A2780 cells. N = 10 in each group. (C) Quantification of tibialis anterior (TA), gastrocnemius (GA), and quadriceps femoris (QF) muscle wet weight normalized by initial body weight. N = 7 in each group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, value significantly different from corresponding value of tumor-free vehicle-treated group by two-way ANOVA followed by Tukey’s multiple comparison test post hoc analysis. @p < 0.05, value significantly different from corresponding value of tumor-bearing vehicle-treated group.