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. 2021 Feb;10(2):675–684. doi: 10.21037/tlcr-20-754

Figure 2.

Figure 2

Kaplan-Meier estimates for OS in bone metastatic LADC patients according to KRAS mutational status and therapeutic modalities including BTx and RTx. (A) LADC patients with tumors harboring KRAS mutations had significantly shorter median OS than those with KRAS WT tumors (median OSs were 5.1 vs. 10.2 months, respectively; P=0.008). (B) Patients receiving BTx had significantly increased median OS (vs. BTx-naive patients; median OS were 10.1 vs. 4.3 months, respectively, P=0.007). (C) Similarly, median OS was also significantly increased in LADC patients receiving RTx compared to those who did not receive RTx (median OSs were 11 vs. 5.9 months, respectively P=0.021). BTx, bisphosphonate therapy; LADC, lung adenocarcinoma; OS, overall survival; RTx, radiation therapy; WT, wild-type.