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. 2021 Feb;13(2):1172–1186. doi: 10.21037/jtd-21-49

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2021 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Dynein light chain roadblock-type 2 (DYNLRB2) and mouse homolog of ß1 spectrin (SPTBN1) correlated enrichment gene analysis with gene set enrichment analysis (GSEA). GSEA results showed that high DYNLRB2 and SPTBN1 co-expression was enriched in drug metabolism cytochrome P450 (A), cardiac muscle contraction (B), and retinol metabolism (C). Downregulated DYNLRB2 and SPTBN1 expressions were associated with homologous recombination (D), progesterone-mediated oocyte maturation (E), and base excision repair (F).