Table 2. Univariate and multivariate Cox proportional hazard regression analysis between clinical variables and OS.
| Variables | Group | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Sex | Male | 1 | 0.46 | 1 | 0.32 | |
| Female | 0.83 (0.50–1.37) | 0.75 (0.42–1.32) | ||||
| Age | ≤65 years | 1 | 0.29 | 1 | 0.30 | |
| >65 years | 1.35 (0.77–2.37) | 1.41 (0.73–2.72) | ||||
| Stage | I–III stage | 1 | 0.01 | 1 | 0.51 | |
| IV stage | 2.30 (1.19–4.44) | 1.29 (0.61–2.70) | ||||
| Smoking | Yes | 1 | 0.98 | 1 | 0.58 | |
| No | 1.00 (0.60–1.70) | 0.84 (0.46–1.54) | ||||
| Mutation type | exon 19 | 1 | 0.19 | 1 | 0.97 | |
| exon 21 | 1.20 (0.92–1.55) | 1.00 (0.74–1.36) | ||||
| Primary lung cancer | Controlled | 1 | 0.73 | 1 | 0.99 | |
| Progressive | 0.90 (.050–1.61) | 1.01 (0.50–2.02) | ||||
| Extracranial metastasis | Absent | 1 | 0.91 | 1 | 0.65 | |
| Present | 1.03 (0.62–1.71) | 0.86 (0.44–1.67) | ||||
| Occurrence of brain metastases | ≤16 months | 1 | 0.00 | 1 | 0.00 | |
| >16 months | 0.18 (0.10–0.32) | 0.15 (0.08–0.30) | ||||
| Number | ≤3 | 1 | 0.00 | 1 | 0.00 | |
| >3 | 3.18 (1.83–5.50) | 2.86 (1.52–5.36) | ||||
| Size | ≤2 cm | 1 | 0.04 | 1 | 0.47 | |
| >2 cm | 1.73 (1.03–2.91) | 0.80 (0.44–1.47) | ||||
| Symptoms | None | 1 | 0.37 | 1 | 0.64 | |
| Yes | 1.28 (0.75–2.12) | 0.86 (0.47–1.60) | ||||
| ECOG score | ≤2 | 1 | 0.00 | 1 | 0.00 | |
| >2 | 4.98 (2.99–8.29) | 4.43 (2.44–8.05) | ||||
| CEA (μg/mL) | ≤10 | 1 | 0.45 | 1 | 0.21 | |
| >10 | 1.23 (0.72–2.08) | 1.48 (0.80–2.71) | ||||