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. 2021 Feb 25;11:621098. doi: 10.3389/fimmu.2020.621098

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Copyright © 2021 Akiyama, Ohtsuki, Berry, Liang, Goronzy and Weyand

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Giant Cell Arteritis in the Temporal Artery. Classic histopathologic and immunophenotypic findings of temporal arteritis in a 78-year old woman presenting with headaches. Panel (A) Transmural arterial inflammation with marked luminal narrowing caused by intimal proliferation which creates a slit-like lumen. Multinucleated giant cells are concentrated in the medial layer (H&E x125) Panel (B) CD68-positive histiocytes accumulating within the medial and adventitial layers of the artery with only scattered histiocytes in the intimal layer (x100). Panel (C): CD4⁺ T cells with a similar pattern of distribution as the CD68⁺ macrophages (x100). Panel (D) Infrequent CD8⁺ T cells within the T cell infiltrates (x100).