Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 25;10:612337. doi: 10.3389/fonc.2020.612337

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Shriwas, Mohapatra, Mohanty and Dash

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Overview of m6A regulation in Chemotherapy, Immunotherapy, and Radiotherapy- 1) Chemotherapeutic drugs Cisplatin, Kinase inhibitor modulates m6A regulator (Writer-METTL3, Raeder-YTHDF1, Eraser-ALKBH5, FTO) stabilizes the oncogene mRNA and induces chemoresistance. 2) Tumor immuno microenvironment (TIME) (B cells, dendritic cells, T cells, NK cells, fibroblast) activated by m6A regulator and induces immunotherapy resistance for cancer cells. 3) Radiation induces m6a regulator and stabilizes mRNA of cancer stem cell. In the figure, the small upward black arrow indicates “upregulation” and the downward black arrow indicates “down regulation”.