Table 3.
Diagnostic accuracy of protein biomarkers individually.
| Protein | Number tested from ILULU-TB cohort | ROC AUC in ILULU-TB study (%) | ROC AUC in AE-TBC study (%) |
|---|---|---|---|
| Complement FH | 292 | 70 (64–76) | 58 (53–62) |
| IP-10 | 282 | 66 (60–73) | 82 (79–86) |
| IFN-gamma | 284 | 66 (60–72) | 80 (76–84) |
| SAA | 263 | 65 (58–71) | 83 (80–86) |
| VEGF | 278 | 64 (57–71) | 70 (65–74) |
| Haptoglobin | 263 | 64 (58–71) | 62 (57–66) |
| SAP | 267 | 64 (57–71) | 58 (53–63) |
| Transthyretin | 292 | 61 (55–68) | 78 (74–82) |
| Apo-CIII | 292 | 58 (51–64) | 65 (61–70) |
| Ferritin | 263 | 57 (50–64) | 78 (75–82) |
| tPA | 263 | 57 (50–64) | 72 (68–76) |
| Alpha-2-M | 267 | 57 (50–64) | 54 (49–58) |
| Fibrinogen | 263 | 56 (49–63) | 73 (69–77) |
| TGF-alpha | 284 | 55 (49–62) | 73 (69–77) |
| TNF-alpha | 284 | 53 (46–59) | 69 (65–74) |
| MMP-9 | 292 | 53 (47–60) | 59 (53–64) |
| Apo-AI | 292 | 52 (45–59) | 69 (65–73) |
| Procalcitonin | 263 | 52 (45–59) | 68 (63–72) |
| IFN-alpha-2 | 284 | 52 (45–58) | 67 (62–71) |
| MMP-2 | 292 | 52 (45–58) | 54 (49–59) |
| CRP | 267 | 51 (43–58) | 84 (81–87) |
| IL-1RA | 283 | 51 (44–58) | 63 (58–68) |
Areas under the receiver operating characteristic curve (ROC AUCs) for the performance of each protein in distinguishing TB (n = 146) from OD (n = 146) are shown, regardless of HIV status or site. Proteins are listed in descending order of performance in the ILULU-TB cohort with the numbers of patients for which results were obtained for that protein. ROC AUCs are shown as percentages. Results from the AE-TBC study are shown to the right for comparison (6). Bracketed values indicate 95% confidence intervals.