Table 4.

Performance of the seven-protein signature from the AE-TBC study in the ILULU-TB cohort.

	AE-TBC cohort (discovery set)	ILULU-TB cohort (validation set)
ROC AUC	91 (89–93)
Sensitivity	85 (80–90)	98 (94–100)
Specificity	85 (81–88)	12 (7–19)
PPV	71 (65–76)	52 (45–58)
NPV	93 (90–95)	88 (64–99)

For this analysis, the entire AE-TBC cohort was used as the discovery set (n = 701), and the whole sample of the ILULU-TB cohort as the validation set (n = 249). Results are shown with the threshold for defining a case of TB at the default setting (p > 0.5). All results are given as percentages. PPV, positive predictive value. NPV, negative predictive value. Bracketed values represent 95% confidence intervals.