Table 7.
Performance of a new 22-protein signature derived from Random Forests analyses.
| Training set | Test set | |
|---|---|---|
| Sensitivity | 72 (61–81) | 73 (56–86) |
| Specificity | 80 (70–88) | 71 (54–85) |
| PPV | 77 (66–86) | 71 (54–85) |
| NPV | 75 (65–83) | 73 (56–86) |
| After adjustment of cut-off for increased sensitivity | ||
| Sensitivity | 82 (73–90) | 92 (78–98) |
| Specificity | 64 (53–74) | 58 (41–74) |
| PPV | 69 (59–77) | 68 (53–80) |
| NPV | 79 (68–88) | 88 (69–97) |
| After adjustment of cut-off for increased specificity | ||
| Sensitivity | 65 (54–75) | 43 (27–61) |
| Specificity | 89 (80–94) | 95 (82–99) |
| PPV | 85 (74–92) | 89 (65–99) |
| NPV | 72 (63–81) | 63 (49–76) |
This analysis was performed using data on the ILULU-TB cohort only (n = 249). The same patients with the same allocations to training and test sets were used as for the GDA analyses (Table 4).