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. 2021 Feb 25;12:617251. doi: 10.3389/fimmu.2021.617251

Figure 4.

Figure 4

Protection of endothelial cells from DENV- and rEIII-induced damage and metabolic burden under treatment with Nlrp3 and caspase-1 inhibitors. Dose-dependent elevation of mitochondria superoxide levels under DENV and rEIII treatment (A). Suppression of mitochondria superoxide levels and induction of surface thrombomodulin expression under treatment with Nlrp3 and caspase 1 inhibitors Z-WHED-FMK and OLT1177, respectively (B, C). Amelioration of DENV- and rEIII-induced thrombocytopenia in C57BL/6J mice under OLT1177 treatment (D). n = 6, and ## p < 0.01 vs. the untreated groups; *p < 0.05 and **p < 0.01 vs. the vehicle groups.