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. 2021 Feb 25;13:640677. doi: 10.3389/fnagi.2021.640677

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Copyright © 2021 Boutajangout, Zhang, Kim, Abdali, Prelli and Wisniewski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TW1 passive immunotherapy reduces biochemical tau pathology in the hTau/PS1 mice model. Densitometric analysis of the blots from the soluble fraction indicates that an equal amount of tau protein was used in treated vs. control animals (A,D). PHF-1 staining shows a decrease of pathological tau in treated animals compared to the controls (*p = 0.03; two-tailed t-test; B). A significant reduction was also observed in the ratio of PHF1/Tubilin (***p = 0.0006; two-tailed t-test; C). With CP13 antibody immunoblotting a reduction of tau pathology in treated animals vs. controls is observed (***p = 0.0007; two-tailed t-test; E). A comparable effect was observed in the ratio CP13/Tubulin (**p = 0.0014; two-tailed t-test; F).