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. 2021 Feb 25;15:628983. doi: 10.3389/fnins.2021.628983

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Copyright © 2021 Kriska, Janeckova, Kirdajova, Honsa, Knotek, Dzamba, Kolenicova, Butenko, Vojtechova, Capek, Kozmik, Taketo, Korinek and Anderova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical representation of the changes observed in adult mice. According to our immunohistochemical analyses, Wnt signaling inhibition (dnTCF4 or Dkk1) led to the differentiation of neural stem/progenitor cells to astrocytes, while activation of the pathway (Ex3; constitutively active β-catenin) promoted neurogenesis. A similar impact of Wnt signaling manipulation after ischemia was also confirmed by the patch-clamp technique. Larger cells represent a greater effect of Wnt signaling after ischemia. Dkk1, Dickkopf 1; dnTCF4, dominant negative T-cell factor 4; Ex3, exon 3.