Figure 3.

Ex vivo PD-L1 siRNA dextran NP biodistribution in orthotopic tumors. Quantification of fluorescent signal intensity in tumors, kidneys, liver, spleen, lungs, heart, intestine, and muscle measured ex vivo after PD-L1-siRNA dextran NP treatment 24 h after the second injection (group 1, black bars, n = 4) and 48 h after the second injection (group 2, grey bars, n = 5). ^#p < 0.05, ^##p < 0.01 (compared to the signal measured in the tumor 24 h post second injection). **p < 0.01, ***p < 0.005 (compared to the signal measured in the tumor 48 h post second injection).