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. 2021 Feb 25;10:614365. doi: 10.3389/fonc.2020.614365

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Copyright © 2021 Pacheco-Torres, Penet, Krishnamachary, Mironchik, Chen and Bhujwalla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo PD-L1 protein levels decrease is related to dextran accumulation in the tumor and to mRNA changes. (A) Correlation between the PD-L1 protein levels, represented by immunoblotting intensity ratio of PD-L1 to GAPDH, and the tumor/muscle fluorescence ratio in tumors treated with the siRNA/dextran complex. (B) Correlation between the protein levels of PD-L1, represented by immunoblotting intensity ratio of PD-L1 to GAPDH, and the levels of PD-L1 mRNA, represented by PD-L1 fold change relative to control, in tumors treated with the siRNA/dextran complex.