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. 2021 Feb 25;12:602221. doi: 10.3389/fendo.2021.602221

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Copyright © 2021 Lin, Fan, Zhang and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Number of total and asymptomatic patients in 2005–2019. The number of patients with total primary hyperparathyroidism (PHPT) markedly increased by 11.8 times from 2005–2007 to 2017–2019, and the proportion of asymptomatic patients increased by 5 times from 2005–2007 to 2017–2019. (B, C) Trends of serum parathyroid hormone (PTH) and calcium levels pre- and intraoperatively and within 24 months after parathyroidectomy. Serum PTH and calcium levels decreased to the lower limit of normal 1–2 days after resection, then increased to a peak of normal range at 1 month and then reached a rather sustainable plateau at 6–24 months. (D) Number of patients with parathyroid adenoma, hyperplasia, and carcinoma in 2005–2019. The number and proportion of patients with parathyroid adenoma, hyperplasia and carcinoma were 280 (77.6%), 67 (18.6%), and 14 (3.9%), respectively.