Table 2.
Clinical and biochemical data from PCOS according to quartiles of prolactin levels.
| Variables | PRL ≤ 186.85 (n = 175) | 186.99–235.74 (n = 170) | 235.77–318.03 (n=232) | PRL>318.03 (n = 215) | P-value |
|---|---|---|---|---|---|
| Age | 31(28–34) | 28.5(27–31) | 29(27–31) | 27(26–31)** | 0.000 |
| Systolic pressure (mmHg) | 121(110–128) | 113(98–124) | 117(106–127) | 115(106–12) | 0.369 |
| Diastolic pressure (mmHg) | 78(68–83) | 73(62–84) | 77(70–81) | 78(70.5–83) | 0.841 |
| BMI (kg/m2) | 26.13(22.83–27.89) | 23.38(21.63–24.848) | 22.86(20.45–25.81) | 22.58(20.50–24.68) | 0.095 |
| WC (cm) | 90(82–95) | 82(74–88) | 80(73–88) | 81(78–86)** | 0.000 |
| HC (cm) | 100(92–106) | 92.5(88–100) | 93(88–97) | 93(90–98)* | 0.001 |
| Waist–hip ratio | 0.89(0.85–0.92) | 0.86(0.85–0.90) | 0.86(0.81–0.89) | 0.88(0.85–0.92) | 0.110 |
| Basal serum PRL (mIU/L) | 137.11(107.06–155.76) | 209.20(195.42–227.58) | 275.91(265.71–287.79) | 396.28(353.25–472.53)** | 0.000 |
| Basal serum LH (IU/L) | 9.61(7.08–14.28) | 9.83(6.21–13.94) | 8.57(5.02–11.34) | 9.0(6.07–12.03)* | 0.001 |
| Basal serum FSH (IU/L) | 7.0(6.02–8.47) | 6.45(5.30–7.16) | 6.60(5.50–8.06) | 6.58(6.03–7.59) | 0.810 |
| LH/FSH | 1.40(1.02–1.94) | 1.55(0.98–2.44) | 1.21(0.76–2.03) | 1.32(0.87–1.77)** | 0.000 |
| Basal serum E2 (pmol/L) | 162(108–217) | 202(125–269) | 186(143–252) | 182(111–218.5) | 0.345 |
| Basal serum T (nmol/L) | 2.17(1.64–2.67) | 2.17(1.66–2.86) | 2.15(1.72–3.02) | 1.91(1.35–2.69) | 0.074 |
| FINS (pmol/L) | 91.6(65.3–138.1) | 87.1(50.9–145.4) | 72(41.3–98) | 81.6(52.3–91.25)* | 0.003 |
| FPG (mmol/L) | 5.2(4.9–5.5) | 5.2(4.9–5.6) | 5.1(4.9–5.4) | 5.1(4.9–5.6) | 0.372 |
| HOMA-IR | 2.81(1.3–4.19) | 2.39(1.59–3.78) | 2.33(1.25–3.87) | 2.20(1.02–3.34)* | 0.006 |
| HOMA-β | 129.77(81.75–219.72) | 112.29(78.08–164.75) | 111.03(67.35–193.47) | 104.48(58.59–163.14)* | 0.001 |
| TG (mmol/L) | 1.43(1.09–2.26) | 1.32(0.93–1.88) | 1.03(0.88–2.08) | 1.33(0.88–1.82)* | 0.017 |
| TC (mmol/L) | 4.78(4.21–5.29) | 4.79(4.120–5.29) | 4.74(4.06–5.35) | 4.98(4.49–5.33) | 0.827 |
| LDL-C (mmol/L) | 2.74(2.37–3.20) | 2.45(2.10–3.26) | 2.73(2.30–3.10) | 2.88(2.45–3.39) | 0.810 |
| HDL-C (mmol/L) | 1.23(1.05–1.33) | 1.30(1.14–1.58) | 1.30(1.19–1.46) | 1.31(1.16–1.54)* | 0.005 |
| AST (U/L) | 18(15–24) | 18(17–20) | 19(15–20) | 19(15.5–25.5) | 0.256 |
| ALT (U/L) | 21(15–30) | 22(15–28) | 17(13–29) | 21 (15–26) | 0.123 |
Parameters were not normally distributed and data are presented as quartiles. The rank sum test was used to compare differences between patients and controls.
*P < 0.05 versus four groups, **P < 0.001 versus four groups.