Table 2.
Bone Density, Strength, and BMA in Women and Men by Quartiles of FSH
| Women | Q1 17.9-55.2 IU/L (n = 59) | Q2 55.2-71.3 IU/L (n = 60) | Q3 71.3-85.2 IU/L (n = 59) | Q4 85.2-180.0 IU/L (n = 60) | P trend |
|---|---|---|---|---|---|
| Spine trabecular BMD (mg/cm3) | 65.7 (58.6-72.7) | 66.6 (59.5-73.7) | 63.8 (56.8-70.8) | 58.3 (51.3-65.3) | 0.12 |
| Spine integral BMD (mg/cm3) | 183.9 (175.1-192.7)* | 179.7 (170.8-188.5) | 180.9 (172.1-189.7) | 169.3 (160.6-178.1) | 0.03 |
| Spine compressive strength index (mg2/cm4) | 110.5 (94.2-129.5)* | 100.0 (85.2-117.4) | 93.0 (79.3-109.0) | 82.0 (70.0-96.1) | 0.008 |
| Total hip trabecular BMD (mg/cm3) | 51.1 (43.5-58.7) | 47.6 (40.2-55.0) | 47.4 (39.7-55.0) | 43.1 (35.7-50.5) | 0.16 |
| Total hip cortical BMD (mg/cm3) | 504.1 (495.0-513.3) | 504.8 (495.9-513.7) | 514.0 (504.8-523.2) | 501.4 (492.5-510.3) | 0.99 |
| Total hip integral BMD (mg/cm3) | 208.5 (199.5-217.5) | 205.8 (197.1-214.6) | 211.5 (202.4-220.6) | 199.5 (190.7-208.3) | 0.28 |
| Femoral neck trabecular BMD (mg/cm3) | 29.1 (20.1-38.1) | 27.1 (18.4-35.8) | 25.5 (16.4-34.6) | 17.3 (8.5-26.1) | 0.07 |
| Femoral neck cortical BMD (mg/cm3) | 522.2 (511.3-533.0) | 520.7 (510.2-531.2) | 527.2 (516.3-538.1) | 521.5 (510.9-532.1) | 0.86 |
| Femoral neck integral BMD (mg/cm3) | 219.8 (210.4-229.3) | 216.1 (206.9-225.2) | 221.5 (212.0-231.0) | 210.4 (201.2-219.6) | 0.27 |
| Lumbar spine areal BMD (g/cm2) | 1.090 (1.046-1.134) | 1.075 (1.031-1.119) | 1.058 (1.014-1.102) | 1.033 (0.989-1.076) | 0.06 |
| Total hip areal BMD (g/cm2) | 0.841 (0.812-0.869)* | 0.823 (0.795-0.851) | 0.834 (0.805-0.863) | 0.800 (0.772-0.828) | 0.08 |
| Femoral neck areal BMD (g/cm2) | 0.798 (0.771-0.825)* | 0.786 (0.759-0.812) | 0.790 (0.762-0.817) | 0.755 (0.728-0.782) | 0.04 |
| (L1-L4) BMA (%) | 53.5 (51.5-55.6)* | 54.4 (52.3-56.5)* | 54.5 (52.4-56.6)* | 58.4 (56.4-60.5) | 0.002 |
| Men | Q1 2.6-7.6 IU/L (n = 61) | Q2 7.6-12.9 IU/L (n = 61) | Q3 12.9-24.5 IU/L (n = 61) | Q4 24.5-99.8 IU/L (n = 62) | P trend |
| Spine trabecular BMD (mg/cm3) | 75.3 (67.4-83.1) | 79.5 (71.5-87.5) | 71.4 (63.6-79.2) | 75.7 (67.6-83.8) | 0.75 |
| Spine integral BMD (mg/cm3) | 188.4 (179.0-197.9) | 195.0 (185.3-204.6) | 194.0 (184.6-203.3) | 192.6 (182.9-202.3) | 0.57 |
| Spine compressive strength index (mg2/cm4) | 149.6 (127.9-175.0) | 175.9 (149.9-206.4) | 178.0 (152.3-208.0) | 156.9 (133.5-184.4) | 0.61 |
| Total hip trabecular BMD (mg/cm3) | 70.6 (62.1-79.0) | 66.9 (58.1-75.7) | 63.2 (57.4-71.7) | 64.2 (55.6-72.9) | 0.25 |
| Total hip cortical BMD (mg/cm3) | 524.2 (515.0-533.4) | 526.8 (517.1-536.4) | 529.0 (519.7-538.3) | 529.9 (520.4-539.4) | 0.37 |
| Total hip integral BMD (mg/cm3) | 227.7 (217.6-237.9) | 221.8 (2111.1-232.4) | 223.7 (213.4-234.0) | 226.0 (215.5-236.4) | 0.85 |
| Femoral neck trabecular BMD (mg/cm3) | 46.2 (35.9-56.5) | 40.7 (30.0-51.5) | 35.2 (24.8-45.6) | 34.6 (24.0-45.1) | 0.09 |
| Femoral neck cortical BMD (mg/cm3) | 535.3 (524.7-545.9) | 538.9 (527.8-550.1) | 535.4 (524.6-546.2) | 541.9 (531.0-552.9) | 0.51 |
| Femoral neck integral BMD (mg/cm3) | 232.5 (221.9-243.0) | 227.9 (216.8-238.9) | 223.9 (213.2-234.6) | 228.4 (217.6-239.3) | 0.50 |
| Lumbar spine areal BMD (g/cm2) | 1.220 (1.167-1.272) | 1.243 (1.188-1.297) | 1.268 (1.214-1.322) | 1.233 (1.177-1.288) | 0.56 |
| Total hip areal BMD (g/cm2) | 0.973 (0.937-1.009) | 0.966 (0.930-1.003) | 0.976 (0.940-1.013) | 0.962 (0.925-1.000) | 0.79 |
| Femoral neck areal BMD (g/cm2) | 0.903 (0.869-0.937) | 0.901 (0.867-0.936) | 0.900 (0.865-0.934) | 0.890 (0.855-0.925) | 0.62 |
| (L1-L4) BMA (%) | 54.4 (52.2-56.6) | 54.3 (52.1-56.6) | 54.3 (52.1-56.5) | 53.6 (51.3-55.8) | 0.63 |
Values are adjusted for age, subgroup (A or B), estradiol, and testosterone. Values are means (95% CIs).
Abbreviations: BMA, bone marrow adiposity; BMD, bone mineral density.
Significantly different from quartile 4: *P < 0.05.