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. 2021 Feb 25;12:612078. doi: 10.3389/fphar.2021.612078

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Copyright © 2021 Ahmad, Khan, Ali, Jo, Park, Ikram and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fisetin improved cognitive functions in the D-gal-injected mice (A and B). Histograms showing the spontaneous alternation behavior (%) and the number of arm entries in the Y-maze test. (C). Latency to reach the hidden platform during the training days. (D). Latency on day fifth. (E). The time spent in the target quadrant during the probe test on day 5. (F). The number of crossings over the hidden platform location during the probe test on day 5. (G). The swimming speed of the mice in the MWM test. n = 10 mice per group for behavioral analysis, number of experiments = 3. *p < 0.05 represents control vs. D-gal treated mice, #p < 0.05, represents D-gal vs. D-gal + Fis. Con: Control, D-gal: d-galactose, Fis: Fisetin, Hippo: Hippocampus.