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. 2021 Feb 4;12(12):933–945. doi: 10.1093/jmcb/mjaa043

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© The Author(s) (2020). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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HDAC4 interacts with IκBα and p65. (A and B) Immunoblotting analysis of phosphorylated (p-) or total IKKβ, p65, and IκBα, HDAC4, or ACTIN (loading control throughout) during LPS or TNFα challenge in BMDCs or HEK293T cells. HDAC4 knockdown was performed by using siRNA or shRNA. (C) Endogenous interactions between HDAC4 and IKKβ, p65, or IκBα. BMDCs were left untreated or treated with LPS (100 ng/ml) and HEK293T cells were treated with TNFα (20 ng/ml) for the indicated times before coimmunoprecipitation (coIP) and immunoblotting (IB) analyses.