Figure 5.

Quantification of junctional and labyrinth zone in placental tissue at gestation day 20 (G20) from reduced uterine perfusion pressure (RUPP) and Sham-operated dams in response to vehicle or a soluble guanylate cyclase (sGC) stimulator (Riociguat 10 mg/kg/day). A: average surface area (mm²) of the junctional zone. B: average surface area (mm²) of the labyrinth zone. C: surface area of the junctional zone (mm²) normalized to total junctional zone and labyrinth zone surface areas (J:(J + L)). D: surface area of the labyrinth zone (mm²) normalized to total junctional zone and labyrinth zone surface areas (L:(J + L)). Each point represents one placenta that was selected based on average whole placental surface area from randomly selected placentas that were near the average placental weight and median location on the uterine horn at harvest. n = 5 Sham rats, n = 5 RUPP rats, n = 5 sGC-treated Sham rats, n = 5 sGC-treated RUPP rats. Scatter plots represent means ± SD. Two-way ANOVA with uncorrected Fisher’s least significant difference post hoc analysis was used for pairwise comparison. *P < 0.05 denotes significant difference between groups.