TABLE 3.

The significant correlations between changes in fecal bacterial abundances at the genus level, and changes in liver health parameters after 12 wk of an RW or WGW intervention in middle-aged overweight and obese adults¹

	RW			WGW
Taxa (Δ 12 wk)	Spearman ρ	P value	FDR P value	Spearman ρ	P value	FDR P value
IHTG (Δ 12 wk)
g_Ruminococcaceae_NK4A214_group	0.67	0.024	NS2	0.54	0.026	NS
ALT (Δ 12 wk)
g_Bacteroides	0.30	NS	NS	−0.44	0.048	NS
g_Bifidobacterium	0.77	0.001	NS	−0.14	NS	NS
g_Faecalibacterium	−0.11	NS	NS	−0.46	0.037	NS
g_Lachnoclostridium	0.60	0.014	NS	−0.20	NS	NS
AST (Δ 12 wk)
g_[Eubacterium]_coprostanoligenes_group	0.53	0.034	NS	0.065	NS	NS
g_Butyricicoccus	0.51	0.045	NS	−0.22	NS	NS
g_Lachnoclostridium	0.51	0.045	NS	−0.48	0.027	NS
g_Lachnospiraceae_NK4A136_group	0.53	0.036	NS	0.35	NS	NS
g_Ruminiclostridium_6	0.10	NS	NS	0.46	0.036	NS
CRP (Δ 12 wk)
g_Butyricicoccus	−0.58	0.025	NS	−0.052	NS	NS
g_Lachnospiraceae_NK4A136_group	−0.68	0.007	NS	0.36	NS	NS
g_Parabacteroides	0.54	0.041	NS	0.25	NS	NS
g_Uncultured	−0.59	0.023	NS	−0.16	NS	NS
GGT (Δ 12 wk)
g_[Eubacterium]_coprostanoligenes_group	−0.21	NS	NS	0.50	0.021	NS
g_Erysipelotrichaceae_UCG-003	0.55	0.028	NS	−0.071	NS	NS
β-Hydroxybutyrate (Δ 12 wk)
g_Erysipelotrichaceae_UCG-003	−0.027	NS	NS	0.67	0.002	NS
g_Lachnospiraceae_ND3007_group	−0.10	NS	NS	0.48	0.036	NS
g_Ruminococcus_2	0.13	NS	NS	0.46	0.049	NS
g_Streptococcus	0.61	0.011	NS	0.48	0.040	NS
SAA (Δ 12 wk)
g_Anaerostipes	−0.23	NS	NS	0.52	0.018	NS
g_Blautia	−0.29	NS	NS	0.53	0.015	NS
g_Butyricicoccus	−0.46	NS	NS	0.46	0.036	NS

¹Values represent the Spearman ρ correlation coefficients, n = 16 (RW) or n = 21 (WGW). ALT, alanine transaminase; AST, aspartate transaminase; CRP, C-reactive protein; FDR, false discovery rate; GGT, γ-glutamyltransferase; IHTG, intrahepatic triglyceride; RW, refined wheat; SAA, serum amyloid A; WGW, whole grain wheat; Δ, differential change over time.

²NS, nonsignificant: P value > 0.05.