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. Author manuscript; available in PMC: 2021 Mar 11.
Published in final edited form as: Endocrine. 2019 Nov 14;67(1):95–108. doi: 10.1007/s12020-019-02124-3

Figure 1.

Figure 1.

LKO mice demonstrate partial induction of FGF21 in adipose tissue FGF21 circulating levels and gene expression in fl/fl and LKO mice fed with chow and KD. a Circulating FGF21 is significantly induced in fl/fl mice with KD consumption and ad libitum access to food and water. In LKO mice, FGF21 is detectable at low levels at baseline and is induced 4-fold with KD. The arrows highlight the differences in Y axes: LKO KD represents a tiny fraction compared to fl/fl KD. b FGF21 gene expression in liver from fl/fl and LKO mice is shown. The FGF21 expression is not detectable in LKO mice. c FGF21 expression is detected in adipose depots, including BAT, eWAT and IWAT at baseline, and small inductions are seen with KD. LKO mice show a specific increase in FGF21 in EWAT with KD consumption. FGF21 gene expression in all the tissues is normalized to the hepatic expression of chow-fed fl/fl mice. N = 7–8 mice/group. Nd: not detectable. *Significantly different compared to all other groups