Table 1.

Circulating Metabolic Parameters in ad lib fed mice consuming chow or ketogenic diet. Data are mean±SEM. LKO, Liver specific FGF21 knockout; KD, ketogenic diet, fl/fl, flox/flox. Significance p<.05 by ANOVA.

	Chow-fed			KD-Fed
Metabolite	fl/fl	LKO		fl/fl	LKO
β-Hydroxybutyrate (mM)	0.15±0.02c,d	0.15±0.01c,d		1.56±0.2a,b	1.49±0.27a,b
Triglycerides (mg/dL)	58.14±7.47	82.18±18.26c		43.91±4.96b	75.27±16.34
Cholesterol (mg/dL)	92.02±7.64d	108.2±13.69d		96.04±12.57d	144.24±15.56a,b,c
Glucose (mg/dL)	175.3±8.8c,d	168.9±9.5c,d		119.4±18.6a,b	126.6±19.6a,b
Insulin (ng/mL)	0.66±0.17c,d	0.64±0.26c,d		0.12±0.05a,b	0.17±0.03a,b
ALT (IU/L)	14.54±0.24d	12.57±2.3d		27.86±4.42	35.15±4.94a,b

^aSignificantly different from Chow fed WT;

^bSignificantly different from Chow fed LKO;

^cSignificantly different from KD fed WT;

^dSignificantly different from KD fed LKO;