Table 3. Antibacterial Activity of Compounds With an NNSN Motif Comprising pyrazolyl thioureas.
| compound | SA Newman |
SA Lac |
||
|---|---|---|---|---|
| MIC (μM) | MIC (μg/mL) | MIC (μM) | MIC (μg/mL) | |
| 3af | 10 | 2.66 | ND | ND |
| 3bb | 2.5 | 0.67 | 5 | 1.67 |
| 3bc | 1.25 | 0.32 | 2.5 | 0.63 |
| 3bd | 2.5 | 0.63 | 10 | 2.53 |
| 3be | 5 | 1.33 | ND | ND |
| 3bf | 20 | 5.61 | ND | ND |
| 3bg | 0.625 | 0.20 | 5 | 1.61 |
| 3bh | 0.625 | 0.16 | 2.5 | 0.63 |
| 3bk | 10 | 2.63 | 20 | 5.27 |
| 3bl | 10 | 2.48 | ND | ND |
| 3bm | 10 | 2.32 | 20 | 4.65 |
| 3bn | 1.25 | 0.37 | 5 | 1.48 |
| 3bo | 20 | 4.72 | ND | ND |
| 3ca | 5 | 1.54 | 5 | 1.54 |
| 3cg | 20 | 5.05 | ND | ND |
| 3ch | 0.15 | 0.05 | ND | ND |
a
In all cases, 50 μM copper sulfate was present. MIC: Minimum inhibitory concentration. Pyrazolyl thioureas: 3bb, 3bd, 3be, 3bf, 3bg, 3bk, and 3ca. Pyrazolyl carbothioamides: 3af, 3bc, 3bh, 3bl, 3bm, 3bn, 3bo, 3cg, and 3ch. None of the pyrazolyl ureas 3aa, 3ab, 3ac, and 3ad exhibited activity against SA Newman or SA Lac. None of the compounds showed activity against either SA Newman or SA Lac in the absence of copper (II) in the (micromolar) concentration range investigated. Details are provided in the Supporting Information section.