Table 1.

Overview of detected circRNAs in AML samples and healthy HSPCs in relation to the genes from which they were transcribed

	HSPCs	AML	AML	NPM1mut	CBF		Splice factor mutation
Subset	Healthy	All_dx	All_rl	NPM1	t(8;21)	inv16	U2AF1	SF3B1	SRSF2
Samples	16	61	18	20	14	11	6	5	6*
circRNAs	6463	6834	9 052	6091	7202		7188
Derived from no. genes	2949	3076	3 561	2932	3161		3125
Highly expressed genes	7509	6681	13 039
Highly expressed genes expressing circRNAs, n (%)	2091 (27.8)	1842 (27.6)	6 310 (48.4)
circRNA abundance, median	1.85 E-04	2.13 E-04	2.72 E-04	1.58 E-04	2.37 E-04		1.66 E-04
DE_linear		4478		4763	5813		3625
DE_circ		82		119	130		56
DE circRNA isoforms		30		124	138		42
DE_both		38		57	63		10
% of DE_circ		46.3		47.9	48.5		23.8

DE, differentially expressed; DE_both, genes that differentially expressed circular and mRNA transcripts in AML vs healthy samples; DE_circ, genes that differentially expressed circRNAs in AML vs healthy samples but did not show differential expression of the parental gene; dx, diagnosis; rl, relapse.

^*One patient was double mutant for SF3B1 and SRSF2.