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Percentage decrease in oxygen saturation p50 relative to unmodified HbS
| Globin analysis in sample | 2,3-BPG | |||
|---|---|---|---|---|
| βS-globin | α-globin | 5.0 mM | 9.7 mM | 14.2 mM |
| acetyl-iMet- | acetyl-iMet-/iMet-/unmodified (1:2:1) | 38% | nd* | nd |
| iMet- | acetyl-iMet-/iMet-/unmodified (1:3:1) | 14%, 12% | 12% | 12% |
| Unmodified | acetyl-iMet-/iMet- (1:1) | 10%, 5% | 16.5% | 25% |
nd, not done.
Due to the limited amount of protein, only 1 concentration of 2,3-BPG was tested.
