Table 1.
Top 10 genes selected by TWAS analysis
| Tissue | Gene name | Chromosome | TWAS.Z | TWAS.P |
|---|---|---|---|---|
| Muscle skeleton | ANKRD44 | 2 | 3.8381 | 0.0001 |
| RIC3 | 11 | 3.6172 | 0.0003 | |
| AC005154.6 | 7 | 3.5112 | 0.0004 | |
| PARD3 | 10 | 3.4069 | 0.0007 | |
| GGCT | 7 | 3.3363 | 0.0008 | |
| Peripheral blood | CRIM1 | 2 | −3.6781 | 0.0002 |
| ZNF880 | 19 | 3.6694 | 0.0002 | |
| NCKIPSD | 3 | −3.629 | 0.0003 | |
| CCR3 | 3 | −3.5323 | 0.0004 | |
| R3HCC1 | 8 | 3.5037 | 0.0005 |
Note: The GWAS summary data for hand OA was derived from the UK Biobank (UK Biobank fields: 20002), which contains 452,264 White British individuals, including 37,782 osteoarthritis patients. The TWAS. P and TWAS. Z values were calculated by the FUSION approach (http://gusevlab.org/projects/fusion/)
TWAS Transcriptome-Wide Association Study, GWAS Genome-Wide Association Study, TWAS P TWAS P value, TWAS Z TWAS Z score