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. 2021 Mar 10;23:81. doi: 10.1186/s13075-021-02458-2

Table 2.

The candidate genes identified by both TWAS and mRNA expression profiles of osteoarthritis

Gene name Chromosome TWAS.Z TWAS.P Log2fold change
DHRS3 1 −2.699 0.0070 −1.8451
SKP2 5 1.9814 0.0475 1.3556
IRS2 13 −2.130 0.0331 2.0001
TOB1 17 1.9970 0.0458 −2.6653
PPP1R15A 19 2.2334 0.0255 −2.1270

Note: Using the GWAS summary data of hand osteoarthritis (OA), transcriptome-wide association study (TWAS) was conducted using the FUSION approach. The mRNA expression profiles of knee OA was acquired from the Gene Expression Omnibus database (accession number: GSE114007). The common candidate genes were finally detected by comparing the significant genes identified by TWAS with the differently expressed genes detected by the mRNA expression profiles

TWAS Transcriptome-Wide Association Study, TWAS P TWAS P value, TWAS Z TWAS Z score