Table 2.
Gene name | Chromosome | TWAS.Z | TWAS.P | Log2fold change |
---|---|---|---|---|
DHRS3 | 1 | −2.699 | 0.0070 | −1.8451 |
SKP2 | 5 | 1.9814 | 0.0475 | 1.3556 |
IRS2 | 13 | −2.130 | 0.0331 | 2.0001 |
TOB1 | 17 | 1.9970 | 0.0458 | −2.6653 |
PPP1R15A | 19 | 2.2334 | 0.0255 | −2.1270 |
Note: Using the GWAS summary data of hand osteoarthritis (OA), transcriptome-wide association study (TWAS) was conducted using the FUSION approach. The mRNA expression profiles of knee OA was acquired from the Gene Expression Omnibus database (accession number: GSE114007). The common candidate genes were finally detected by comparing the significant genes identified by TWAS with the differently expressed genes detected by the mRNA expression profiles
TWAS Transcriptome-Wide Association Study, TWAS P TWAS P value, TWAS Z TWAS Z score