Figure 4.

Bone marrow MPO deficiency in 5/6 nephrectomized mice on a high-fat/high-cholesterol diet decreases MPO-dependent oxidation in atherosclerotic lesions. Mass spectrometric quantification of oxidized amino acids in aortic proteins from irradiated 5/6 nephrectomized LDLr ^−/− mice (CKD) mice with WT bone marrow (CKD-bMPOWT) and with bone marrow MPO deficiency (CKD-bMPOKO) after 16 weeks on a high-fat/high-cholesterol diet. A, 3-chlorotyrosine and B, 3-nitrotyrosine expressed as ratios to the precursor amino acid, tyrosine, in μmol/mol (n= 12 each). ∗p < 0.05.