Figure 1.

Comparison of reprogramming efficiency for a group of nuclear factors.A, schematics for factors induced somatic cell reprogramming. B, Oct4-GFP+ colonies induced by indicated factors cultured in iCD1 culture medium at day 7. OKS: Oct4(O), Klf4(K), Sox2(S). (n = 6 wells from three independent experiments; mean ± SD, two-tailed, unpaired t test; ∗∗∗p < 0.0001). C, Oct4-GFP⁺ colonies induced by OKS+DsRed/OKS+Sall4 in iCD1 culture medium. (n = 6 wells from three independent experiments; mean ± SD, two-tailed, unpaired t test; ∗∗∗p < 0.0001). D, images for (C). The scale bars represent 5 mm.