Effect of Ephx3 deficiency on transepidermal water loss (TEWL) and in combination with deficiencies in Ephx1 and Ephx2.A, TEWL of dorsal skin was determined on postnatal day 2 from wild-type (WT), heterozygous (Ephx3+/−), and homozygous null (Ephx3−/−) Ephx3-deficient pups (±SEM, n = 7–19 each genotype, ∗p < 0.05 versus WT). B, effects of individual knockouts and in combination. C, comparison of TEWL in wild-type, Ephx3−/−, and the triple knockout Ephx1/2/3−/−. ±SEM, n = 5 to 37/genotype ∗p < 0.05 versus WT.