Figure 2.

Example study in Framework 1. A, illustration of how the Inforna database is used to identify small molecules interacting with a disease-causing RNA of interest. Inforna compares secondary structure motifs in the target of interest with those found in the database and then outputs small molecules predicted to bind to one or more of the secondary structure motifs in the target RNA. The figure was adapted from Disney and Angelbello (56) with permission. Copyright (2016) American Chemical Society. B, the modular assembly technique where moieties binding neighboring secondary structure motifs are linked together to increase potency.