Figure 5.

Pocket analysis in RNA structures performed by Warner et al. (17). Complex structures have good quality pockets (green/blue), whereas stem loops have poorer pockets (orange and red). A and B, currently targeted RNA structures with good quality pockets. C, currently targeted RNA structures with low-to-medium quality pockets. D and E, aspirational targets with potential good quality pockets. The figure was reprinted with permission from Springer Nature Customer Service Centre GmbH: Springer Nature, Nature Reviews Drug Discovery (17), Copyright 2018.