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Analysis of kinetics of inhibition of cytochrome P450 3A4-catalyzed inhibition of 7-benzoyl debenzylation by ketoconazole.A, basic model; B, ketoconazole (red: no inhibitor; green: 0.12 μM ketoconazole; and blue: 4 μM ketoconazole). The upper section (r/σ) is a residual plot. See similar analyses for ritonavir, indinavir, and itraconazole in Figures S11–S13, with values for k−3, k4, and k−4 adjusted.
