Figure 2.

Inhibition of cytochrome P450 3A4-catalyzed 7-benzoyl quinoline O-debenzylation and testosterone 6β-hydroxylation. The steady-state rates are plotted as functions of (log₁₀) inhibitor concentration, with the inhibitor indicated on the x-axis labels. A, C, E, G, and I (left panels): 7-benzoyl quinoline O-debenzylation; B, D, F, H, and J (right panels): testosterone 6β-hydroxylation. IC₅₀ values are shown on the graphs. All fits had r² values of ≥0.94. The 95% confidence intervals were as follows: A, 0.07 to 0.17 μM; B, 0.08 to 0.22 μM; C, 0.05 to 0.23 μM; D, 0.05 to 0.24 μM; E, 0.22 to 0.60 μM; F, 0.22 to 0.36 μM; G, 0.14 to 0.31 μM; H, 0.52 to 1.07 μM; I, 1.1 to 3.8 μM; and J, 0.94 to 2.7 μM.