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Pre–steady-state kinetics of inhibition of cytochrome P450 3A4-catalyzed O-debenzylation of 7-benzoyl quinoline. Plots of ΔF410/>510 are shown for A, ketoconazole; B, clotrimazole; C, ritonavir; D, indinavir; and E, itraconazole. The (final) inhibitor concentrations are shown on the individual graphs. The data were fit to the equation y = A(1 − e−k1t) + ksst (Table 1).
