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Initial rates of binding of inhibitory ligands to P450 3A4
| Ligand | Concentration, μMa | kobs, s−1 |
|---|---|---|
| Ketoconazole | 2 | 137 |
| Clotrimazole | 4 | 235 |
| Ritonavir | 4 | 650 |
| Indinavir | 4 | 70 |
| Itraconazole | 2 | 195 |
P450, cytochrome P450.
Final concentration in flow cell. In each case, the final concentration of P450 3A4 was 2 μM.
