Table 1.

Voltage-clamp parameters of the different Nav1.7 mutants

Genotype	Activation				Fast inactivation			Current density
	n	V1/2 (mV)	Slope (V/s)	Gmax (pS)	n	V1/2 (mV)	Slope (V/s)	(pA/pF)
WT	31	−18.3 ± 5.91	8.91 ± 1.24	76.62 ± 53.13	30	−84.21 ± 6.82	6.67 ± 1.42	−416.5 ± 291.5
I848T	30	−28.06 ± 5.42	8.99 ± 1.48	41.01 ± 29.51	32	−86.32 ± 5.11	6.48 ± 1.36	−252.8 ± 167.6
I848E	20	−24.1 ± 6.91	11.09 ± 1.77	7.79 ± 4.59	15	−84.05 ± 6.6	6.99 ± 1.93	−53.29 ± 47.09
F1432L WT	18	−20.02 ± 4.03	9.14 ± 0.83	110.0 ± 91.61	20	−83.82 ± 4.07	6.70 ± 1.55	−340.4 ± 229
F1432L IT	14	−40.76 ± 7.91	9.9 ± 2.03	15.89 ± 13.42	9	−86.02 ± 4.69	5.59 ± 1.11	−91.68 ± 53.48
F832L WT	14	−18.24 ± 5.42	9.24 ± 1.14	124.7 ± 86.09	11	−84.06 ± 7.23	6.58 ± 1.12	−445.6 ± 315.4
F832L IT	14	−25.7 ± 5.13	8.94 ± 1.26	72.34 ± 50.26	11	−82.89 ± 4.93	6.13 ± 0.74	−406.9 ± 246.9
F1320L WT	9	−15.94 ± 5.7	8.64 ± 1.27	124.6 ± 93.52	9	−85.97 ± 4.03	5.9 ± 1.18	−550.4 ± 427
F1320L IT	14	−25.70 ± 6.2	9.82 ± 1.26	81.79 ± 46.08	19	−84.37 ± 4.7	6.38 ± 1.12	−278.2 ± 80.83
F1436L WT	15	−19.20 ± 3.62	8.94 ± 1.37	69.16 ± 49.75	9	−73.96 ± 3.51	5.59 ± 1.39	−194.3 ± 107.6
F1436L IT	17	−29.91 ± 2.5	9.21 ± 1.23	34.21 ± 27.26	13	−74.40 ± 4.14	5.93 ± 0.79	−111.0 ± 64.26

All data are presented as mean ± SD.