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The thermal stability of OGG1 is dependent on certain cysteines.A, CD spectra of OGG1 mutants compared with the WT at 25 °C. Ellipticity of the ⍺-helical structure was measured at 208 nm as a function of temperature. B, the melting temperature (Tm) was estimated as the temperature at which 50% of the secondary structure has denatured. The WT has a Tm of 43.1 °C; each of the mutants had a different effect on the extent of stability.
