Figure 8.

ORco functional assays of antagonist mixtures. Box plots depicting relative AgamORco luminescence responses induced by 100 μM OA (ORcoRAM2) in the absence (OA) or presence of low concentrations of antagonists and mixtures thereof, consisting of 25 μM each. The examined blends display enhanced mosquito repellent activities that are probably the result of additive rather than a synergistic effect as depicted here. Different letters (a, b, etc.) indicate statistically significant differences between tested compounds (one-way ANOVA, Df = 7; F = 88.4; p= 1.36E-11; followed by Mann–Whitney U test with Bonferroni correction, p < 0.05). CA, cumin alcohol; CRV, carvacrol; OA, ORco agonist; OCT, (2E,4E)-2,4-octadienal.