Figure 5.

ApoC-III drives mitochondrial dysfunction and oxidative stress.A, principal component analysis of 2773 proteins with ≥2 unique peptides. B, heat map of 1365 proteins with q ≤ 0.1 between normal medium (NM), procalcifying medium (PM), and PM + apoC-III. Red box highlights enriched proteins in PM + apoC-III versus NM and PM. C–D, apoC-III and superoxide dismutase 2 (SOD-2) are significantly enriched in PM + apoC-III quantified by MS, respectively. E, differentially enriched proteins in NM versus PM + apoC-III. F, differentially enriched proteins in PM versus PM + apoC-III. n = 4 donors, day 7 and day 14 data.