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Overview of working model depicted for Pseudomonas aeruginosa. This model is also investigated for Staphylococcus aureus. CP inhibits iron uptake and induces iron-starvation responses in the absence of heme. Here, we test the hypothesis that heme, an alternative iron source, will protect P. aeruginosa and S. aureus from Fe starvation induced by CP. CP, calprotectin; IM, inner membrane; OM, outer membrane.
